Abeer Ramadan1, Amin Hamed2, Amal Jamee3
1. Pharmacist, Indonesian Hospital
2. Dean of Postgraduate studies, Assoc. Professor of Pharmacology, Al Azhar University.
3. Consultant Cardiologist, Head of Cardiology department, Al Shifa Hospital.
Background: Metabolic syndrome is a multi-component disorder associated with a high risk of atherosclerotic cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including dietary habits, insulin resistance, hyperlipidemia and visceral obesity.
Statins are lipid lowering drugs used to decrease the cardiovascular complication in high risk patients with dyslipidemia.
Objectives: Comparative study to evaluate the overall effect of statins on metabolic syndrome patients and on blood glucose level over six months of treatment.
Methodology: To achieve this purpose, eighty-eight (88) patients with metabolic syndrome were selected. The study population was divided into two groups, control group which consisted of thirty-seven (37) patients and the statins treated group (atorvastatin 20mg, atorvastatin 40mg and simvastatin 20mg) which consisted of fifty-one (51) patients. The study was carried out at the (UNRWA) clinics in North Gaza and Indonesian hospital.
Biochemical tests were carried out on fasting blood glucose and lipid profile.
Results: The study showed a significant decrease in lipid components by statins as follows, triglyceride level decreased from (239.37±116.57mg/dl to 180.96±82.41mg/dl at six months), total cholesterol decreased from (210.±47.70mg/dl to 175.29±43.07mg/dl at six months), LDL-c from (119.51±44.95mg/dl to 101.33±38.36mg/dl at six months) and non-HDL-c from (167.39±46.73mg/dl to 135.84±43.44mg/dl at six months).
Conclusion: The results indicated that statins are an effective treatment on metabolic syndrome patients due to their significant decrease in lipid components. Two new cases of diabetes mellitus out of twenty-one were discovered in statins treated group at three months.
Recommendation: Metabolic syndrome is a serious problem and hence increased awareness is recommended. These patients need more studies and for longer periods to evaluate the effect of Statins on health.